Perbandingan Mula dan Lama Kerja antara Lidokain, Lidokain — Bupivakain dan Bupivakain pada Blok Epidural

Tahun 2000 Volume 35 Nomor 1
Oleh : Marwoto

Latar belakang: Anestesi regional terutama blok epidural semakin berkembang dan meluas pemakaiannya. mengingal banyak keuntungan yang ditawarkan diantaranva relatif lebih murah, pengaruh sistemik minimal, menghasilkan analgesi yang adekuat dan mampu mencegah respon stres secara lebih sempurna . Salah satu kelemahannya adalah mula kerja lidokain cepat dan lama kerja juga cepat. Sedang bupivakain mula kerja lambat walaupun laina kerja panjang. Penelitian ini bertujuan mencari bukti obyektif apakah mula kerja kombinasi lidokain – bupivakain secepat lidokain dan lama kerjanya sepanjang bupivakain.

Pasien dan Metoda: Penelitian eksperimental murni dengan metoda acak buta ganda uji klinis tahap II, dengan bentuk rancangan posttest only control group design, dilakukan di kamar bedah RS. Roemani Semarang, periode Agustus 1997 – Juni 1999. Subyek penelitian adalah 60 penderita program elektig bedah digestif dan urologi yang memenuhi kriteria inklusi blok epidural.
 
Hasil : Mula kerja lidokain – hupivakain lebih cepat secara bermakna dibanding bupivakain dan lebih lambat dibanding lidokain, Lama kerja lidokain – bupivakain lebih panjang dibanding lidokain dan lebih pendek dibanding bupivakain. keduanya secara bermakna.
 Kesimpulan: Mula kerja lidokain – bupivakain lebih cepat dibanding bupivakain dan lama kerjanya lebih panjang dibanding lidokain

Background: Recently, the use of regional anesthesia, especially epidural block is increased. There are many advantages, i.e. cheaper, minimally systemic response, and gives analgesia perfectly. One of the problem is the induction time or the onset of lidocaine tic short and the duration time is also short. While the onset of hupivacaine is long and the duration time is also long. The objective of this study is to determine whether the onset of combination of lidocaine and bupivacaine, is as short as lidocaine and duration time is as long as bupivacaine.
 
Design: Prospective randomized double blind clinical trial using post test only control group design was performed to 60 patients undergoing digestive and urologic surgeiy in Roemani hospital, in Semarang, August 1997- June 1999.
 
Result: The onset of lidocaine – bupivacaine combination is significantly faster than hupivacaine and signifIcantly slower than lidocaine. The duration time of lidocaine – bupivacaine combination is longer than lidocaine and shorter than bupivacaine, both satistically sigifificant.
 
Conclusion: The onset of lidocaine – hupivacaine coot bination is faster than bupivacaine and the duration time is longer than lidocaine.