Resistensi Beberapa Kuman Penyebab Sinusitis Maksila terhadap Ampisilin di SMF Kesehatan THT RSUP Dr. Kariadi Semarang

Tahun 2000 Volume 35 Nomor 2
Oleh : Muyassaroh, Suprihati

Latar Belakang: Ampisilin merupakan anti infeksi berspektrum luas, mudah di dapat di Rumah Sakit dan Puskesmas dan harganya terjangkau, oleh karena itu masih banyak digunakan untuk terapi infeksi saluran nafas akut termasuk sinusitis maksila. Resistensi kuman terhadap derivat Penisilin telah diketahui, namun resistensi kuman penyebab sinusitis rnaksila terhadap Ampisilin di Bagian THT RSDK belum dilaporkan.
 
Metoda: Suatu penelitian deskriptif dilakukan untuk mengetahui resistensi kuman penyebab sinusitis maksila terhadap Ampisilin . Biakan kuman aerob diambil dan sekret sinus maksilanis secara aseptik kemudian diperiksa tes kepekaan kuman terhadap beberapa macam antibiotika memakai metode difusi
 
Hasil: Selama 3 bulan (Maret – Mei 1999.), didapatkan 52 kasus sinusitis maksila yang memenuhi kriteria inklusi dimasukkan dalam penelitian ini. Terdapat 24 kasus (46, 1%) dengan hasil biakan positif Enterobacter paling banyak ditemukan (45,8%). Hasil tes kepekaan kuman menunjukkan bahwa 58,3% resisten terhadap Ampisilin. terutama enterobakter (90,9%), tetapi seluruh kuman yang ditemukan sensitif Levofloksasin.
 Kesimpulan: Lebih dari 50% kuman yang diisolasi dan sinusistis maksila, resisten terhadap Ampisilin.

Background: Ampicillin is a broad spectrum antibiotic., available in hospitals and health centres with reasonable price, therefore is still used in acute respiratory tract infection treatment, including maxillary sinusitis. Bacterial resistency against Penicillin derivative is well known, but Ampicillin resLctant bacteria from maxillary sinusitis in ENT Department Kariadi Hospital has not been documented.
 
Method : A descriptive study to assess Ampicillin resistant bacteria from maxillary sinusitis cases was done. Aerobic bacteriological culture of maxillary sinus secretion were obtained by aseptic sinus puncture method and antibiotic sensitivity test was done against several antibiotics using disc diffusion method.
 
Result: During 3 months period (March-May 1999) 52 maxillary sinusitis cases who fulfilled the inclusion criteria were included in this study. There were 24 cases (46, 1%) positive bacterial isolates. Enterobacter was the most frequent bacteria (45,8%). Antibiotic sensitivity test result showed that 58,3% bacterial isolates were resistent to Ampicillin, Enterobacter being the most frequent (90,9%). However, all isolated bacteria were sensitive to Levofloxacin.
 
Conclusion: More than 50% bacteria isolated from maxillary sinusitis cases are resistant to Ampicillin.