YODIUM DAN RESPONS AUTOIMUN

Johan S. Masjhur

Iodine excess and iodine deficiency may trigger thyroid autoimmune response. Iodine excess exacerbates the thyroid autoimmunity as iodine induced hyperthyroidism which frequently found in iodine deficiency areas, meanwhile the iodine induced hypothyroidism may be found in normal iodine intake areas. This mechanism is mediated through thyrocid toxiety process and increasing thyroglobuline immunogenity. Continue reading “YODIUM DAN RESPONS AUTOIMUN”

PERKEMBANGAN FETUS DALAM KONDISI DEFISIENSI YODIUM DAN CUKUP YODIUM

Bambang Hartono

Iodine is a trace element present in the human body, and it is essential substrate for the synthesis of the thyroid hormone. Iodine deficiency during pregnancy may results the increase risk of spontaneous abortion, premature birth and early infant death, as well as transient neonatal hyperthyrotropinemia. This deficiency also has a deleterious effect on the development of the infant’s tone, since may cause hypotonia both in the extremities and axial muscles during early life. The deleterious effect is also found for the postural responses (late infant reflexes) but not for the neonatal (so-called primitive) reflexes. This developmental delay does not persist during the course of infancy since catch up can be attained by the age of 6 months. Continue reading “PERKEMBANGAN FETUS DALAM KONDISI DEFISIENSI YODIUM DAN CUKUP YODIUM”

ANALISIS FAKTOR RISIKO COASTAL GOITER

Abdul Razak Thaha, Djunaidi M. Dachlan dan Nurhaedar Jafar

Until recently, risk factors related to coastal goiter in Maluku are still inconclusive. This study was carried out to identify the predominant risk factors of IDD in Maluku. The study was conducted in two group of islands (“Gugus Pulau”) with highest prevalence and two “Gugus Pulau” non-endemic areas. Study subjects were schoolchildren and randomly chosen from those who participated in a mapping study of IDD prevalence in 1996 consist of 117 and 200 for case and control groups respectively. Continue reading “ANALISIS FAKTOR RISIKO COASTAL GOITER”

THE GLOBAL CHALLENGE OF IODINE DEFICIENCY

John T. Dunn

Iodine deficiency affects most of the world’s land mass, and consequently puts a large part of the population at risk. The most damaging effects are increased neonatal mortality and retarded brain development, but others are important, including goiter, hypothyroidism, and socioeconomic deprivation. Several good means are available for correcting iodine deficiency, the best being iodized salt; iodized vegetable oil, iodized water, and iodine tablets have an occasional place as well. Major components of successful IDD control include an effective national program, usually in the Ministry of Health, a national advisory commission that represents all sectors involved with iodine deficiency and its correction, a vigorous education and communication program, and regular and reliable Continue reading “THE GLOBAL CHALLENGE OF IODINE DEFICIENCY”

Peran Limfosit T Helper-1 (TH1) dan T Helper-2 (TH2) pada Patogenesis Artritis Lepra

Tahun 2008 Volume 43 Nomor 1
Oleh : Suyanto Hadi ,Sunarto,Hardyanto S, Triyuliati,Susanto J, FX Hartono

Latar belakang: TH1 CD4+ autoreactive diduga kuat berperan pada patogenesis artritis lepra. Apakah autoimunitas yang terJadi akibat dominansi aktivasi timfosit TH1 atau TH2 pada penderita lepra belum pernah diteliti Continue reading “Peran Limfosit T Helper-1 (TH1) dan T Helper-2 (TH2) pada Patogenesis Artritis Lepra”