Farmakokinetika dalam Terapi
Tahun 1997 Volume 32 Nomor 2
Oleh : I. Nasution
In the concept of rational drug use the pharmacokinetic principle is a necessary toll to design dosage regimens and its frequency of drug administration in a variety of physio logical and pathological condition.
The drug information needed are lipid solubility, ionisation rate absorption, metabolism, distribution, excretion, half-life an bioavailblity, in order to achieve steady state Concentration and produce desired effect and to avoid adverse drug reaction.