Pengaruh Pemberian Klorokuin Terhadap Respons Imun Seluler Mencit
Tahun 1997 Volume 32 Nomor 2
Oleh : Neni
Susilaningsih, Andrew J, Pudjadi, Ratna DP
This research was aimed to know the effect of chloroquine towards the cellular immune response in mice. The research was done in Biochemistry department and Histology department of Medical Faculty UNDIP .
In this study, 130 mice were devided into 3 groups i.e 30 mice (1st group), 70 mice (2nd group) and 30 mine 3rd group). The first group were devided into 3 subgroups : 10 mice not given any immunogen nor drug. This group was proposed to know the ability of macrophage as presenting cells. The second group were devided into 3 subgroups : 30 mice were injected with immunogen, 30 mice were injected with immunogen and chloroquine, and the other 10 mice were not given any immunogen nor drug. This group was proposed to know the proliferative response of lymphocyte at 3rd, 4th and 5th days. The third group were devided into 3 subgroups : 10 mice injected with immunogen, 10 mice were not given any immunogen nor drug. This group was proposed to know the ability of intracellular killing.
The data were analysed by Wilcoxon”s rank sun test, ficantly (p<0.05) decreased the ability of macrophage as presenting cell, decreased the proliferative response of lymphocyte in spleen and decreased the ability of intracellular killing of macrophage. Those, proved that chloroquine decreased the celluler immane response in mice.