Pemeriksaan Serologi Dengue Blot IgG Untuk Konfirmasi Diagnosis Demam Berdarah Dengue
Tahun 1998 Volume 33 Nomor 3
Oleh : Soetono,
Anggoro DB Sacho, PW Irawan, Koeswardono Hendro
Metodologi Penelitian : Penelitian ini menggunakan metode tes diagnostik dengan mengukur sensitivitas, spesifisitas nilai duga positif dan duga negatif. Dalam penelitian ini digunakan sampel sebanyak 211 penderita laki-laki dan perempuan, berumur antara 0 – 14 tahun yang dirawat di Bangsal Infeksi RS Dr. Kariadi Semarang. Untuk menegakkan diagnosis DBD digunakan kriteria WHO 1986 yang telah dimodifikasi (hasil pertemuan Pokja DBD Ciloto 1991) kemudian diperiksa serologi HI dan Dengue Blot. Gold Standard yang digunakan dalam tes diagnostik ini adalah pemeriksaan serologi HI, kemudian dibandingkan dengan hasil pemeriksaan serologi dengue blot IgG dengan tabel 2×2.
Hasil Penelitian : Pada penelitian ini didapatkan hasil secara keseluruhan tes dengue blot IgG mempunyai sensitivitas sebesar 95.62%, spesifisitas 88.23%, nilai duga positif 96.25%, nilai duga negatif 86.36% serta positif palsu sebesar 3.7%. Semakin berat derajat sakit, semakin tinggi hasil tes diagnostik.
Background : Up to now Dengue Haemorrhagie Fever (DHF) is still being a health problem for both health workers and community. DHF may become an epidemic with high mortality rate among children. For establishing the diagnosis of this disease, a sensitive and specific test but simple, chief and give immediate result is needed. At the moment the serologic IgG Dengue Blot test has already been used, but its validity still needs confirmation.
Method : a diagnostic test to know the sensitivity, specificity, positive predictive value and negative predictive value was used. Two hundred and eleven DHF cases, age less than 14 years old, admitted in the infection ward Dept of Pediatrics Dr. Kariadi Hospital were used as sample. Diagnosis of DHF based on modified (1986) WHO criteria (DHF working group Ciloto 1991). All of cases were tested for both HI and IgG Dengue Blot. HI was used as a gold standart.
Result : IgG Dengue Blot had sensitivity 95.6%, specificity 88.23%, positive predictive value 92.25%, negative predictive value 86.36% and false positive 3.7% in diagnosing DHF.
Conclusion : IgG Dengue Blot is a valid test for DHF.