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Latar belakang: Sepertiga kematian perioperatif disebabkan oleh penyakit arteri koronaria. Terdapat angka kejadian iskemi yang tinggi selama perioperatif pada penderita dengan penyakit arteri koronania. Iskemi perioperatif merupakan suatu petunjuk kelainan jantung pasca bedah.
 
Tujuan: Untuk mengidentifikasi interval QTc yang disebabkan oleh induksi anestesi dan intubasi endotrakhea terhadap penderita normal dan penderita dengan penyakit yang iskemik.
 
Bahan dan Cara: Penelitian dilakukan di Bedah Sentral, Rumah Sakit Dr . Kariadi Semarang, pada penderita dengan anestesi general. Empat puluh penderita dengan menggunakan Cohort, dimulai dari Desember 1999 sampai Oktoher 2000. Analisis statistik menggunakun Student’s t test, Chi square test dan paired (test, p<O dinyatakan signifikan. Penderita dibagi dua kelompok: kelompok normal dua puluh penderita dan kelompok suspek penyakit jantung iskemik dua puluh penderita. Semua penderila diperiksa dengan ananinesis, EKG dan pemeriksaan status fisik

Background: One third of death perioperatively is caused by coronary arterial diseases. There is high incidence of ischemia perioperatively in patients with coronary arterial diseases. Ischemia periopera!ivelv is used as a guide of abnormality of heart post operatively.

Objective: To identify QTc interval caused by induction of anesthesia one! endotracheal intubation to normal patients and patients with suspected ischemic heart disease.

Materials and methods: The study was conducted in the central operating theatre, Kariadi Hospital Semarang, Indonesia, on patients with general anesthesia. We used Cohort of fourty patients, started from December 1999 to October 2000 Statistic ana1y used student ‘s t test, clii square test and paired t test, p<O,O was considered signifIcant. The patients were divided into two groups; normal groups were twenty patients and suspected ischemic heart disease groups were twenty. All of the patients were examined by anamnesis, ECG and physical status.

Results: In normal groups, the mean of QTc interval before induction anesthesia was 433, 7 ± 26,65 and after induction was 455,4 23,26 there were sign different t’p< 0,01 In suspected isehemic heart disease groups, before induction was 436.3 ± 29,82 and after induction was 448,3 ± 20,54 there were significantly different p<O. 01). In normal groups, QTc interval before intubation was 455,3 ± 23,26 and after intubation was 453,1 ± 24,4, there were sign different ( 001). in suspected ischiemic heart disease groups, OTc interval before intubation was 418,3 + 20,54 and a/icr intubation was 444,4 :c 26,91, there is no significantly different (p:

conclusions: QTc interval in normal groups and suspect ischemic heart disease groups due to induction of anesthesia were sign prolonged (>440,n seconds). QTc intervals in normal groups and suspect ischemic heart disease significant prolonged after intubation.