Pengaruh Pemberian Hidroklorotizod dan Natrium Bikarbonat terhadap Kadar Kalsium Urin
Tahun 2005 Volume 40 Nomor 2
Oleh : Rifki Muslim
Latar Belakang: Hiperkalsuria pada penderita batu traktus urinarius di Eropa 39 – 40 % dan di Amerika Serikat 43 – 70 %. Sebagian besar batu traktus urinarius adalah kalsium oksalat .Untuk menurunkan kadar kalsium urine dipakai hidroklorotiazid. Natrium bikarbonat diharapkan juga menurunkan kadar kalsium urine . Penelitian ini ditujukan untuk mengetahui apakah pemberian gabungan hidroklorotiazid dengan natrium bikarbonat dapat menurunkan kadar kalsium urine lebih baik dibandingkan pemberian hidroklrotiazid saja
Metode: Penelitian ini merupakan uj klinik acak dengan kontrol secara buta ganda dan randomisasi dilakukan dengan cara blok dengan masing masing kelompok 24 sampel . Kelompok I mendapat campuran hidroklrotiazid 2 x 25 mg/oral tiap hari dengan Natrium bikarbonat 2 x 1000 mg/oral tiap hari dan kelompok II mendapat hidroklrotiazid 2×25 mg/oral tiap hari saja . Data dianalisis secara deskriptif dan uji T dipakai menganalisis perbedaan kedua kelompok dengan menggunakan program SPSS 10,01
Hasil : Sebelum perlakuan , volume urine dan kadar kalsium urine ternyata tidak berbeda bermakna antara kelompok I dengan kelompok II . Setelah perlakuan 6 bulan pada kelompok I kalsium urine menurun secara bermakna (p=0,001) pada kelompok II tidak terjadi penurunan bermakna (p=0.169). Penurunan rerata kalsium urine I dan kelompok II berbeda secara bermakna (p=0,011)
Simpulan : pemberian campuran hidroklorotiazid dan Natrium bikarbonat menurunkan kadar kalsium urine lebih baik dibandingkan pemberian hidroklorotiazid.
Metode: Penelitian ini merupakan uj klinik acak dengan kontrol secara buta ganda dan randomisasi dilakukan dengan cara blok dengan masing masing kelompok 24 sampel . Kelompok I mendapat campuran hidroklrotiazid 2 x 25 mg/oral tiap hari dengan Natrium bikarbonat 2 x 1000 mg/oral tiap hari dan kelompok II mendapat hidroklrotiazid 2×25 mg/oral tiap hari saja . Data dianalisis secara deskriptif dan uji T dipakai menganalisis perbedaan kedua kelompok dengan menggunakan program SPSS 10,01
Hasil : Sebelum perlakuan , volume urine dan kadar kalsium urine ternyata tidak berbeda bermakna antara kelompok I dengan kelompok II . Setelah perlakuan 6 bulan pada kelompok I kalsium urine menurun secara bermakna (p=0,001) pada kelompok II tidak terjadi penurunan bermakna (p=0.169). Penurunan rerata kalsium urine I dan kelompok II berbeda secara bermakna (p=0,011)
Simpulan : pemberian campuran hidroklorotiazid dan Natrium bikarbonat menurunkan kadar kalsium urine lebih baik dibandingkan pemberian hidroklorotiazid.
The Effect of combine Hydroklorotiazide and sodium bicarbonate on urinary calcium concentration.
Background : Hypercalcularia is found in 39-47 % patients with urinary tract stone in Europe and 43 – 70 % in United States.
Most of urinary tract stone is calcium oxalate. Hydroklorotiazide and sodium bicarbonate are used to decreased the calcium coonsentrate in urine. The purpose of this study was to know the effect of combination of sodium bicarbonate and Hydroklorotiazide only.
Methods: The study was a double blind clinical randomized controlled the trial using block randomization with 24 samples in each group. The first group received 2×25 mg Hydroklorotiazide in combination with 2x1000mg sodium bicarbonate orally per day, while the other only received 2×25 mg Hydroklorotiazide orally per day. The data was analyzed descriptively and t-test for testing the differences by using SPSS 10,01 software.
result: Before treatment, urine volume and the calcium concentrate in urine were not significantly different between groups. Six month after treatment , the first group showed that calcium in urine was signifficantly lower compared to the initial data (p=0,001) in the second group the calcium in urine did not decrease significantly (p=0,169), The decrease calciumuria in 1st group was significantly higher than the 2nd group (p=0,011)
Most of urinary tract stone is calcium oxalate. Hydroklorotiazide and sodium bicarbonate are used to decreased the calcium coonsentrate in urine. The purpose of this study was to know the effect of combination of sodium bicarbonate and Hydroklorotiazide only.
Methods: The study was a double blind clinical randomized controlled the trial using block randomization with 24 samples in each group. The first group received 2×25 mg Hydroklorotiazide in combination with 2x1000mg sodium bicarbonate orally per day, while the other only received 2×25 mg Hydroklorotiazide orally per day. The data was analyzed descriptively and t-test for testing the differences by using SPSS 10,01 software.
result: Before treatment, urine volume and the calcium concentrate in urine were not significantly different between groups. Six month after treatment , the first group showed that calcium in urine was signifficantly lower compared to the initial data (p=0,001) in the second group the calcium in urine did not decrease significantly (p=0,169), The decrease calciumuria in 1st group was significantly higher than the 2nd group (p=0,011)
Conclusion: The adsministration of Hydroklorotiazide in combination with sodium bicarbonate decreased the calcium in urine better than adsministration of Hydroklorotiazide only