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Nutrisi adalah essensial unruk aktivitas optimum seluruhfungsifisiologis terutama untuk sistem imun. Penelitian epidemiologis mengenai efek nutrisi terhadap imunitas dan melalui tanda-tanda klinis yang dipertegas oleh terjadinya infeksi pada ke kurangan gizi yang merupakan penyebab utama dan morbiditas dan mortalitas terutama di antara anak-anak di bawah umur 5 tahun . KKP dihubungkan dengan ketidaknormalan yang konsisten pada respon imun, mengecilnya kelenjar timus, penurunan respon hipersensitivitas kulit ripe lambat, menurunnya bentuk roset limfosit T, terutama CD4+, T sel helper, C ( sel, dan menurunnya aktivitas natural sel killer.

Nutrition is essensial for optimum activity of all physiologicalfunctions. This is partcularly true of the immune system. Studies on the effect of nutriton on immunity were prompted by epidemiologic studies which confirmed the clinical impression that infection often superadded on malnutrition, as a mayor cause of morbidity and mortality, particularly among children under 5 years of age. Protein energy malnutrition (PE1v1) is associated with consistent abnormality in immune responses.i.e: thymic atrophy, reduced frequency and magnitude of delayed cutaneous hypersensitivity responses, decreased number of rosette — forming T lymphocytes, particularly CD4+ helper T Cells, CD3+, CD 25+ cells, and decreased natural Killer Cell activity.